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Aggregation Effects and Population-Based Dynamics as a Source of Therapy Resistance in Cancer

1 Nov 2016

Abstract excerpt

OBJECTIVE: Evolution of resistance allows cancer cells to adapt and continue proliferating even when therapy is initially very effective. Most investigations of treatment resistance focus on the adaptive phenotypic properties of individual cells. We propose that the resistance of a single cell to therapy may extend beyond its own phenotypic and molecular properties and be influenced by the phenotypic properties...

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PMID: 28113286
DOI: 10.1109/tbme.2016.2623564

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