Article

A Mathematical Model of Persister Cell Plasticity and Its Impact on Adaptive Cancer Therapy

2025-06-27

Abstract excerpt

The emergence of resistance to therapy remains a significant obstacle to successful treatment in cancer that is driven by somatic evolution. Adaptive therapies represent a novel approach to manage the emergence of resistance, by leveraging the competition between different cell phenotypes to control tumor burden rather than aiming for complete eradication. However, the emergence of phenotypica l y plastic persist...

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Literature Corpus work: 75ca8f1e-19ec-576c-97e9-e8a62efc0500
DOI: 10.1101/2025.06.26.661628

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