Article
The role of memory in non-genetic inheritance and its impact on cancer treatment resistance
2021-02-22
Abstract excerpt
Intra-tumour heterogeneity is a leading cause of treatment failure and disease progression in cancer. While genetic mutations have long been accepted as a primary mechanism of generating this heterogeneity, the role of phenotypic plasticity is becoming increasingly apparent as a driver of intra-tumour heterogeneity. Consequently, understanding the role of plasticity in treatment resistance and failure is a key com...
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Identifiers and source
- Literature Corpus work
- 9169ff21-4595-5e83-9d24-994f2076976f
- DOI
- 10.1101/2021.02.22.431869