Article

The pathogenic role of Succinate-SUCNR1: A critical function that induces renal fibrosis via infiltration of M2 macrophage

2023-08-21

Abstract excerpt

<h4>Background: </h4> Renal fibrosis is a major determinant of progressive loss of kidney function in chronic kidney disease (CKD), and alternatively activated M2 macrophages play an essential role in the progression. Serum succinate level is consistently elevated in diabetes and obesity, and diabetes and obesity are critical causes of CKD, but whether elevated succinate can mediate M2 polarization of macrophages...

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Literature Corpus work: 1f1aaaed-50e4-5a83-bba3-0be15c699296
DOI: 10.21203/rs.3.rs-3243744/v1

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