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NAD+ Improves Cognitive Function and Reduces Neuroinflammation By Ameliorating Mitochondrial Damage and Decreasing ROS Production in Chronic Cerebral Hypoperfusion Models Through Sirt1/PGC-1α Pathway

2021-06-17

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Microglial mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a promising treatment target. NAD + shows anti-inflammatory and anti-oxidant effects in many neurodegenerative disease models, but its role in the chronic cerebral hypoperfusion (CCH) is still unclear. <bold>Methods:</bold> The bila...

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Literature Corpus work: d36b851b-f43d-58a0-b7dc-debb9f873d77
DOI: 10.21203/rs.3.rs-621126/v1

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