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PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus

22 Apr 2024

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies whose production is promoted by autoreactive T follicular helper (TFH) cells. During SLE pathogenesis, basophils accumulate in secondary lymphoid organs (SLO), amplify autoantibody production and disease progression through mechanisms that remain to be defined. Here, we provide evidence for a direct functional...

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PMID: 38649353
DOI: 10.1038/s41467-024-47691-w

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