Article

IL-1β Signalling Modulates T Follicular Helper and Regulatory Cells in Human Lymphoid Tissues

2024-10-03

Abstract excerpt

<h4>Background</h4> Dysregulation of the T follicular helper (Tfh) and T follicular regulatory (Tfr) homeostasis in the germinal center (GC) can result in antibody-mediated autoimmunity. While interleukin-1β (IL-1β) has been shown to be an important modulator of the GC response in animal models via the expression of IL-1 agonist (IL-1R1) and antagonist (IL-1R2) receptors on follicular T cells, such regulation has...

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Literature Corpus work: e1b17ce6-35b2-5082-8e26-6faffba0b14f
DOI: 10.1101/2024.10.02.616222

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