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Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes.

Cancer science - 1 Jun 2023

Komohara Yoshihiro, Kurotaki Daisuke, Tsukamoto Hirotake, Miyasato Yuko, Yano Hiromu, Pan Cheng, Yamamoto Yutaka, Fujiwara Yukio

Abstract excerpt

Tumor-associated macrophages (TAMs) are the most prominent immune cells in the breast cancer microenvironment, and the protumor functions of TAMs are thought to affect cancer progression and resistance to anticancer therapy. Numerous studies using human breast cancer samples, cell lines, and murine breast cancer models have revealed details of the mechanisms by which the protumor functions of TAMs are activated....

Topics

Humans
Animals
Mice
Female
Breast Neoplasms
Macrophages
Phenotype
Immunotherapy
Immune Tolerance
Tumor Microenvironment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36748310
DOI: 10.1111/cas.15751
PMCID: PMC10236637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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