Article

A Single Multipurpose FSH–Blocking Therapeutic for Osteoporosis and Obesity

2022-03-02

Abstract excerpt

<h4>ABSTRACT</h4> Pharmacological and genetic studies over the past decade have established FSH as an actionable target for diseases affecting millions, notably osteoporosis, obesity and Alzheimer’s disease (AD). Blocking FSH action prevents bone loss, fat gain and AD–like features in mice. We recently developed a first–in–class, humanized, epitope–specific FSH blocking antibody, MS-Hu6, with a K D of 7.52 nM. U...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 90ced81c-e320-5d0e-800c-cd9ef43b2b80
DOI: 10.1101/2022.02.28.482279

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Single Multipurpose FSH–Blocking Therapeutic for Osteoporosis and ObesityDOI 10.1101/2022.02.28.482279Read

Synthesis, Structure, Stability, Efficacy, and Safety of a Therapeutic FSH–Blocking AntibodySemantic proximity Read

Evaluation of in vivo bioactivities of recombinant hypo- (FSH 21/18 ) and fully- (FSH 24 ) glycosylated human FSH glycoforms in Fshb null miceSemantic proximity Read

Small Molecule Follicle-Stimulating Hormone Receptor Agonists and AntagonistsSemantic proximity Read

Molecular regulation of follicle-stimulating hormone synthesis, secretion and actionSemantic proximity Read

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulationSemantic proximity Read

In Vivo and In Vitro Impact of Carbohydrate Variation on Human Follicle-Stimulating Hormone FunctionSemantic proximity Read

Recombinant follicle stimulating hormone: development of the first biotechnology product for the treatment of infertilitySemantic proximity Read

A novel peptide antagonist of the human growth hormone receptorSemantic proximity Read

Bioengineered recombinant kisspeptins with extended half-life exhibit novel peripheral function in a large-animal modelSemantic proximity Read

Bioengineering an Ultra-Stable and Cost-Effective FGF2 (NGF2) with Extended Circulatory Half-Life for Next-Generation TherapeuticsSemantic proximity Read

Modulation of Gonadotropins Activity by AntibodiesSemantic proximity Read

Protein Engineering on Human Recombinant Follistatin: Enhancing Pharmacokinetic Characteristics for Therapeutic Application.Semantic proximity Read