Article

Synthesis, Structure, Stability, Efficacy, and Safety of a Therapeutic FSH–Blocking Antibody

2026-08-01

Abstract excerpt

FSH, a glycoprotein secreted by the anterior pituitary gland, has for decades been thought to solely regulate estrogen secretion in females and spermatogenesis in males. Through the use of genetically–engineered mouse models and pharmacological approaches, we and others have shown that FSH has an array of direct actions on somatic tissues, including adipose tissue and bone, as well as on the brain. Thus, inhibitin...

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Literature Corpus work: 05ee73ba-e9f6-58e7-bb0f-c88c3dd58d45
DOI: 10.22541/authorea.15006875/v1

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