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Article

A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance.

BMC genomics - 11 Oct 2017

Sheen Patricia, Requena David, Gushiken Eduardo, Gilman Robert H, Antiparra Ricardo, Lucero Bryan, Lizárraga Pilar, Cieza Basilio, Roncal Elisa, Grandjean Louis, Pain Arnab, McNerney Ruth, Clark Taane G, Moore David, Zimic Mirko

Abstract excerpt

BACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes. However, its complete mechanism of action and resistance remains unclear. RESULTS: We genotyped and sequenced the complete genomes of 68 M. tuberculosis strains isolated from unrelated TB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29020922
DOI: 10.1186/s12864-017-4146-z
PMCID: PMC5637355

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