Article

Characterization of altered molecular mechanisms in Parkinson’s disease through cell type-resolved multi-omics analyses

2022-02-15

Abstract excerpt

Parkinson’s disease (PD) is a progressive neurodegenerative disorder. However, cell type-dependent transcriptional regulatory programs responsible for PD pathogenesis remain elusive. Here, we establish transcriptomic and epigenomic landscapes of the substantia nigra (SN) by profiling 87,733 nuclei obtained from healthy controls and PD patients. Our multi-omic data integration provides functional annotation of 128,...

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Literature Corpus work: 90b85fce-da4f-525e-996e-7e16770c42a1
DOI: 10.1101/2022.02.13.479386

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Characterization of altered molecular mechanisms in Parkinson’s disease through cell type-resolved multi-omics analysesDOI 10.1101/2022.02.13.479386Read

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