Article

Sequencing ultra-rare targets with compound nucleic acid cytometry

2020-09-02

Abstract excerpt

Targeted sequencing enables sensitive and cost-effective analysis by focusing resources on molecules of interest. Existing methods, however, are limited in enrichment power and target capture length. Here, we present a novel method that uses compound nucleic acid cytometry to achieve million-fold enrichments of molecules >10 kbp in length using minimal prior target information. We demonstrate the approach by seque...

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Literature Corpus work: 906dfc71-ed6a-5326-944b-041d5c1d239d
DOI: 10.1101/2020.09.01.278275

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