Article

Targeted Nanopore Sequencing with Cas9 for studies of methylation, structural variants, and mutations

2019-04-11

Abstract excerpt

Nanopore sequencing technology can rapidly and directly interrogate native DNA molecules. Often we are interested only in interrogating specific areas at high depth, but conventional enrichment methods have thus far proved unsuitable for long reads 1 . Existing strategies are currently limited by high input DNA requirements, low yield, short (<5kb) reads, time-intensive protocols, and/or amplification or cloning...

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Literature Corpus work: 7ad44382-1cdb-559c-a4a3-98533eca608d
DOI: 10.1101/604173

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