Article

CA19-9 promotes liver metastasis of pancreatic cancer through E-selectin mediated extravasation

2026-04-10

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) frequently metastasizes to the liver, which drives patient mortality. CA19-9 is elevated in most PDAC tumors and is widely used as a clinical biomarker. Elevated serum levels are associated with poor outcomes. However, whether CA19-9 functionally contributes to metastatic progression has not been fully defined, in part because mice lack endogenous CA19-9 expression. Here, us...

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Literature Corpus work: 0331538a-acc2-5edd-9a20-ffbceebe05a4
DOI: 10.64898/2026.04.08.717301

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