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Article

Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies.

Seminars in cancer biology - 1 Jun 2017

Le Large T Y S, Bijlsma M F, Kazemier G, van Laarhoven H W M, Giovannetti E, Jimenez C R

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy, characterized by a high metastatic burden, already at the time of diagnosis. The metastatic potential of PDAC is one of the main reasons for the poor outcome next to lack of significant improvement in effective treatments in the last decade. Key mutated driver genes, such as activating KRAS mutations, are concordantly expressed in...

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Share to Adenocarcinoma
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Source

Identifiers

PMID: 28366542
DOI: 10.1016/j.semcancer.2017.03.008

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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