Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KRAS mutation and epithelial-macrophage interplay in pancreatic neoplastic transformation.

International journal of cancer - 15 Oct 2018

Bishehsari Faraz, Zhang Lijuan, Barlass Usman, Preite Nailliw Z, Turturro Sanja, Najor Matthew S, Shetuni Brandon B, Zayas Janet P, Mahdavinia Mahboobeh, Abukhdeir Abde M, Keshavarzian Ali

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) is characterized by epithelial mutations in KRAS and prominent tumor-associated inflammation, including macrophage infiltration. But knowledge of early interactions between neoplastic epithelium and macrophages in PDA carcinogenesis is limited. Using a pancreatic organoid model, we found that the expression of mutant KRAS in organoids increased (i) ductal to acinar gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Pancreas

Share to Pancreatic Neoplasms

Share to Precancerous Conditions

Share to RAW 264.7 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 29756386
DOI: 10.1002/ijc.31592
PMCID: PMC6128758

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KRAS mutation and epithelial-macrophage interplay in pancreatic neoplastic transformation.PMID 29756386Read ↗

KRAS mutation: The booster of pancreatic ductal adenocarcinoma transformation and progressionSemantic proximity Read ↗

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancerSemantic proximity Read ↗

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancerSemantic proximity Read ↗

Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer.Semantic proximity Read ↗

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesisSemantic proximity Read ↗

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.Semantic proximity Read ↗

KRAS mutations take different trajectories to drive pancreatic transformation.Semantic proximity Read ↗

Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells.Semantic proximity Read ↗

Crosstalk between KRAS and miRNAs in pancreatic cancer: Opportunities for its diagnosis, prognosis and therapeutic intervention (Review).Semantic proximity Read ↗

Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression.Semantic proximity Read ↗

Inhibition of miR-21 Regulates Mutant KRAS Effector Pathways and Intercepts Pancreatic Ductal Adenocarcinoma Development.Semantic proximity Read ↗

KRAS-Driven Tumorigenesis and KRAS-Driven Therapy in Pancreatic Adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.