Article

Restoration of Fbxo7 expression in dopaminergic neurons restores tyrosine hydroxylase in a mouse model of Parkinson’s disease

2024-09-30

Abstract excerpt

Mutations in FBXO7 are linked to an atypical parkinsonism. Conditional knock out (KO) of Fbxo7 in dopaminergic neurons in a mouse model caused a neurodegenerative phenotype, including a significant reduction in striatal TH staining at 6 weeks of age and a significant loss of dopaminergic neurons in the SNpc. To test whether re-expression of Fbxo7 could act as a treatment to prevent or restore TH expression in the...

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Literature Corpus work: 90433ebf-0108-5e0d-a38e-eb66f153c4e5
DOI: 10.1101/2024.09.28.615591

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