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Article

Dopaminergic neuronal loss and dopamine-dependent locomotor defects in Fbxo7-deficient zebrafish.

PloS one - 1 Jan 2012

Zhao Tianna, Zondervan-van der Linde Herma, Severijnen Lies-Anne, Oostra Ben A, Willemsen Rob, Bonifati Vincenzo

Abstract excerpt

Recessive mutations in the F-box only protein 7 gene (FBXO7) cause PARK15, a mendelian form of early-onset, levodopa-responsive parkinsonism with severe loss of nigrostriatal dopaminergic neurons. However, the function of the protein encoded by FBXO7, and the pathogenesis of PARK15 remain unknown. No animal models of this disease exist. Here, we report the generation of a vertebrate model of PARK15 in zebrafish....

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Source

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Identifiers

PMID: 23133663
DOI: 10.1371/journal.pone.0048911
PMCID: PMC3487786

Genes

FBXO7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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