Article

A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease

2024-12-21

Abstract excerpt

In Parkinson’s disease (PD), dopaminergic neurons (DANs) in the midbrain gradually degenerate, with ventral substantia nigra pars compacta (SNc) DANs exhibiting greater vulnerability. However, it remains unclear whether specific molecular subtypes of ventral SNc DANs are more susceptible to degeneration in PD, and if they contribute to the early motor symptoms associated with the disease. We identified a subtype o...

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Literature Corpus work: 38079605-3e74-54ff-8a9e-9925a30067e4
DOI: 10.1101/2024.12.20.629776

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