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Article

Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism‐like phenotype in mice

6 Aug 2016

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Share to Cellular transport and secretion
Share to Parkinson's Disease Mechanisms and Treatments
Share to Ubiquitin and proteasome pathways

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27497298
DOI: 10.15252/embj.201593585

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Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism‐like phenotype in micePMID 27497298Read ↗

Structure and Function of Fbxo7/PARK15 in Parkinson's Disease.Semantic proximity Read ↗

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.Semantic proximity Read ↗

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Pathophysiological mechanisms linking F-box only protein 7 (FBXO7) and Parkinson’s disease (PD)Semantic proximity Read ↗

FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivoSemantic proximity Read ↗

FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provides a target for Pink1 phosphorylation <i>in vivo</i>Semantic proximity Read ↗

F-box only protein 7 gene in parkinsonian-pyramidal disease.Semantic proximity Read ↗

Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient miceSemantic proximity Read ↗

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin‐like domainSemantic proximity Read ↗

USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkinSemantic proximity Read ↗

Expanding the Clinical and Mutational Spectrum of FBXO7-Related Parkinsonism: A Novel Italian Family and Comprehensive Literature Review.Semantic proximity Read ↗

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.Semantic proximity Read ↗

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