Article

Inhibition of <i>O</i> -GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

2023-12-15

Abstract excerpt

The O -GlcNAc transferase (OGT) is an essential enzyme that mediates protein O -GlcNAcylation, a unique form of posttranslational modification of many nuclear and cytosolic proteins. Recent studies observed increased OGT and O -GlcNAcylation levels in a broad range of human cancer tissues compared to adjacent normal tissues, indicating a universal effect of OGT in promoting tumorigenesis. Here, we show that OGT...

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Literature Corpus work: 9041b8a4-0371-5944-9275-a52a344ea318
DOI: 10.1101/2023.12.14.571787

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