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Article

Computational Tool to Study Perturbations in Muscle Regulation and Its Application to Heart Disease.

Biophysical journal - 18 Jun 2019

Barrick Samantha K, Clippinger Sarah R, Greenberg Lina, Greenberg Michael J

Abstract excerpt

Striated muscle contraction occurs when myosin thick filaments bind to thin filaments in the sarcomere and generate pulling forces. This process is regulated by calcium, and it can be perturbed by pathological conditions (e.g., myopathies), physiological adaptations (e.g., β-adrenergic stimulation), and pharmacological interventions. Therefore, it is important to have a methodology to robustly determine the...

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Identifiers

PMID: 31126584
DOI: 10.1016/j.bpj.2019.05.002
PMCID: PMC6588827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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