Article

Computational tool to study perturbations in muscle regulation and its application to heart disease

2019-02-19

Abstract excerpt

Striated muscle contraction occurs when myosin thick filaments bind to thin filaments in the sarcomere and generate pulling forces. This process is regulated by calcium, and it can be perturbed by pathological conditions (e.g., myopathies), physiological adaptations (e.g., β-adrenergic stimulation), and pharmacological interventions. Therefore, it is important to have a methodology to robustly determine the mechan...

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Literature Corpus work: 86395af8-7f0a-5385-91a7-1db5a2a456a8
DOI: 10.1101/548404

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