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Evolution of Siderophore Pathways in Human Pathogenic Bacteria

3 Apr 2014

Abstract excerpt

Ornibactin and malleobactin are hydroxamate siderophores employed by human pathogenic bacteria belonging to the genus Burkholderia. Similarities in their structures and corresponding biosynthesis gene clusters strongly suggest an evolutionary relationship. Through gene coexpression and targeted gene manipulations, the malleobactin pathway was successfully morphed into an ornibactin assembly line. Such an...

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PMID: 24707815
DOI: 10.1021/ja501597w

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