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Discovery of lydiamycin A biosynthetic gene cluster in the plant pathogen <i>Rhodococcus fascians</i> guides structural revision and identification of molecular target

2024-11-13

Abstract excerpt

<h4>ABSTRACT</h4> The natural products actinonin and matlystatin feature an N -hydroxy-2-pentyl-succinamyl (HPS) chemophore that facilitates metal chelation and confers their metalloproteinase inhibitory activity. Actinonin is the most potent natural inhibitor of peptide deformylase (PDF) and exerts antimicrobial and herbicidal bioactivity by disrupting protein synthesis. Here, we used a genomics-led approach to...

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Literature Corpus work
e920033f-b81f-5bde-86ae-32bc74ffe48d
DOI
10.1101/2024.11.13.623425
Open publication

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Discovery of lydiamycin A biosynthetic gene cluster in the plant pathogen <i>Rhodococcus fascians</i> guides structural revision and identification of molecular targetDOI 10.1101/2024.11.13.623425
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