Article

Cell-Free Biosynthesis to Evaluate Lasso Peptide Formation and Enzyme-Substrate Tolerance

2020-11-27

Abstract excerpt

Lasso peptides are ribosomally synthesized and post-translationally modified peptide (RiPP) natural products that display a unique lariat-like structure. Owing to a rigid topology, lasso peptides are unusually stable towards heat and proteolytic degradation. Some lasso peptides have been shown to bind human cell-surface receptors and exhibit anticancer properties, while others display antibacterial or antiviral ac...

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Literature Corpus work: 6fb98d28-85d4-50ee-b413-7c526be2127a
DOI: 10.1101/2020.11.25.399105

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