Article

Unfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant Activity

2024-02-09

Abstract excerpt

Protein S (PS), the critical plasma cofactor for the anticoagulants tissue factor (TF) pathway inhibitor (TFPI) and activated protein C (APC), circulates in two functionally distinct pools: free (anticoagulant) or bound to complement component 4b-binding protein (C4BP) (anti-inflammatory). Acquired free PS deficiency is detected in several viral infections, but its cause is unclear. Here, we identified a shear-dep...

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Literature Corpus work: 90352108-9742-5be7-a9f7-c55415bf22c3
DOI: 10.1101/2024.02.08.579463

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