Article
Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2018
Plautz William E, Sekhar Pilli Vijaya Satish, Cooley Brian C, Chattopadhyay Rima, Westmark Pamela R, Getz Todd, Paul David, Bergmeier Wolfgang, Sheehan John P, Majumder Rinku
Abstract excerpt
OBJECTIVE: PS (protein S) is a plasma protein that directly inhibits the coagulation FIXa (factor IXa) in vitro. Because elevated FIXa is associated with increased risk of venous thromboembolism, it is important to establish how PS inhibits FIXa function in vivo. The goal of this study is to confirm direct binding of PS with FIXa in vivo, identify FIXa amino acid residues required for binding PS in vivo, and use...
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