Article
The various states of von Willebrand factor and their function in physiology and pathophysiology.
Thrombosis and haemostasis - 1 Apr 2014
Huck Volker, Schneider Matthias F, Gorzelanny Christian, Schneider Stefan W
Abstract excerpt
The specific interactions of von Willebrand factor (VWF) with the vessel wall, platelets or other interfaces strongly depend on (a shear-induced) VWF activation. Shear flow has been shown to induce a conformational transition of VWF, but is modulated by its thermodynamic state (state-function relationship). The state in turn is determined by physical (e.g. vessel geometry), physico-chemical (e.g. pH) and...
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