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Article

Misfolding of vWF to pathologically disordered conformations impacts the severity of von Willebrand disease.

Biophysical journal - 2 Sept 2014

Tischer Alexander, Madde Pranathi, Moon-Tasson Laurie, Auton Matthew

Abstract excerpt

The primary hemostatic von Willebrand factor (vWF) functions to sequester platelets from rheological blood flow and mediates their adhesion to damaged subendothelium at sites of vascular injury. We have surveyed the effect of 16 disease-causing mutations identified in patients diagnosed with the bleeding diathesis disorder, von Willebrand disease (vWD), on the structure and rheology of vWF A1 domain adhesiveness...

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Source

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Identifiers

PMID: 25185554
DOI: 10.1016/j.bpj.2014.07.026
PMCID: PMC4156683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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