Article

Shear-Mediated Platelet Microparticles Demonstrate Phenotypic Heterogeneity as to Morphology, Receptor Distribution, and Hemostatic Function

2023-02-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Implantable cardiovascular therapeutic devices (CTD) including stents, percutaneous heart valves and ventricular assist devices, while lifesaving, impart supraphysiologic shear stress to platelets resulting in thrombotic and bleeding device-related coagulopathy. We previously demonstrated that shear-mediated platelet dysfunction is associated with downregulation of platelet G...

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Literature Corpus work: c21530a2-95d4-5afb-b5ea-e916663f3714
DOI: 10.1101/2023.02.08.527675

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