Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma.

Abstract excerpt

BACKGROUND: Protein S and tissue factor pathway inhibitor (TFPI) act together in down-regulating coagulation. OBJECTIVE: To investigate the TFPI/protein S system in hereditary and acquired protein S deficiency. METHODS: Plasma antigen levels of protein S and full-length TFPI were determined in heterozygous type I protein S-deficient individuals (n=35), patients on oral anticoagulant treatment (OAT) (n=29), oral...

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• Administration, Oral
• Anticoagulants
• Blood Coagulation
• Contraceptives, Oral
• Protein S