Article
Protein S.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Hepner Mirta, Karlaftis Vasiliki
Abstract excerpt
Protein S (PS) is a vitamin K-dependent plasma glycoprotein. Around 60-70% of PS in plasma is noncovalently bound to C4-binding protein (C4BP). Free PS functions as a cofactor that enhances the activity of activated protein C (APC) in the proteolytic degradation of activated factors V and VIII. PS also has a more recently described APC-independent ability to directly inhibit prothrombinase and tenase by direct...
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