Article

Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation

2023-08-07

Abstract excerpt

Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji-domain histone demethylases. The epigenetic remodelling promoted by vitC improves the efficiency of induced pluripotent stem cell derivation, and is required to attain a ground-state of pluripotency in embryonic stem cells (ESCs) that closely mimics the inner cell ma...

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Literature Corpus work: 9028255f-2ed0-528d-8106-670e3f6e294e
DOI: 10.1101/2023.08.07.552254

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