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Vitamin C Rescues in vitro Embryonic Development by Correcting Impaired Active DNA Demethylation

19 Nov 2021

Abstract excerpt

During preimplantation development, a wave of genome-wide DNA demethylation occurs to acquire a hypomethylated genome of the blastocyst. As an essential epigenomic event, postfertilization DNA demethylation is critical to establish full developmental potential. Despite its importance, this process is prone to be disrupted due to environmental perturbations such as manipulation and culture of embryos during in...

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Birth, Development, and Health
Epigenetics and DNA Methylation
Prenatal Screening and Diagnostics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34869387
DOI: 10.3389/fcell.2021.784244

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