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Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells

15 Nov 2019

Abstract excerpt

BACKGROUND: As the precursors of sperm and eggs, human primordial germ cells (hPGCs) emerge as early as weeks 2 to 3 of post-implantation development. Recently, robust hPGC induction models have been established in vitro with different protocols, but global 5mC/5hmC epigenetic reprogramming is not initiated in vitro. Previous studies found that vitamin C can enhance Tet (ten-eleven translocation) enzyme...

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PMID: 31730021
DOI: 10.1186/s13287-019-1427-2

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