Article

Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Defects through Dysregulation of DNA Methylation

2025-05-30

Abstract excerpt

<h4> Abstract </h4> Maternal dietary insufficiencies can reshape the fetal epigenome during gestation, contributing to birth defects and developmental disorders. Vitamin C (VitC) is a critical co-factor for Ten-Eleven- Translocation (TET) DNA demethylases, but the impact of its deficiency on embryonic development has gone largely unappreciated. Here, we show that maternal VitC deficiency in L-gulonolactone oxida...

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Literature Corpus work: 870c6ed5-9894-5b99-8789-182fc74f632a
DOI: 10.1101/2025.05.27.656260

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