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Article

Human-induced pluripotent stem cells for modelling metabolic perturbations and impaired bioenergetics underlying cardiomyopathies.

Cardiovascular research - 22 Feb 2021

Ramachandra Chrishan J A, Chua Jasper, Cong Shuo, Kp Myu Mai Ja, Shim Winston, Wu Joseph C, Hausenloy Derek J

Abstract excerpt

Normal cardiac contractile and relaxation functions are critically dependent on a continuous energy supply. Accordingly, metabolic perturbations and impaired mitochondrial bioenergetics with subsequent disruption of ATP production underpin a wide variety of cardiac diseases, including diabetic cardiomyopathy, dilated cardiomyopathy, hypertrophic cardiomyopathy, anthracycline cardiomyopathy, peripartum...

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Identifiers

PMID: 32365198
DOI: 10.1093/cvr/cvaa125
PMCID: PMC7898957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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