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Article

Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes.

International journal of cardiology - 1 Dec 2018

Ramachandra Chrishan J A, Mehta Ashish, Wong Philip, Ja K P Myu Mai, Fritsche-Danielson Regina, Bhat Ratan V, Hausenloy Derek J, Kovalik Jean-Paul, Shim Winston

Abstract excerpt

BACKGROUND: Preferential utilization of fatty acids for ATP production represents an advanced metabolic phenotype in developing cardiomyocytes. We investigated whether this phenotype could be attained in human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) and assessed its influence on mitochondrial morphology, bioenergetics, respiratory capacity and ultra-structural architecture. METHODS AND...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30177232
DOI: 10.1016/j.ijcard.2018.08.069

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