Article

Fmp30 is a phosphatidylinositol hydrolase that regulates CoQ biosynthesis

2025-05-02

Abstract excerpt

<h4>ABSTRACT</h4> Coenzyme Q (CoQ, ubiquinone) is a redox-active isoprene lipid that supports fundamental enzymatic and antioxidant roles in mitochondria and beyond. Despite CoQ’s importance in organismal health and disease, the mechanisms that regulate its biosynthetic pathway remain elusive. Motivated by this, we mined S. cerevisiae multiomics datasets for genes whose disruptions alter CoQ levels and discovere...

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Literature Corpus work: 8ff3a6c9-d4b7-564a-a2e6-dafbd579da4a
DOI: 10.1101/2025.05.01.651778

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