Article

COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells

2023-11-13

Abstract excerpt

<h4>SUMMARY</h4> Coenzyme Q (CoQ) is a redox lipid that fulfills critical functions in cellular bioenergetics and homeostasis. CoQ is synthesized by a multi-step pathway that involves several COQ proteins. Two steps of the eukaryotic pathway, the decarboxylation and hydroxylation of position C1, have remained uncharacterized. Here, we provide evidence that these two reactions occur in a single oxidative decarboxy...

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Literature Corpus work: d28ee1bb-71e9-5888-9977-efbe1cbc344e
DOI: 10.1101/2023.11.13.566839

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