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Article

Nonfunctional coq10 mutants maintain the ERMES complex and reveal true phenotypes associated with the loss of the coenzyme Q chaperone protein Coq10.

The Journal of biological chemistry - 1 Nov 2024

Novales Noelle Alexa, Feustel Kelsey J, He Kevin L, Chanfreau Guillaume F, Clarke Catherine F

Abstract excerpt

Coenzyme Q (CoQ) is a redox-active lipid molecule that acts as an electron carrier in the mitochondrial electron transport chain. In Saccharomyces cerevisiae, CoQ is synthesized in the mitochondrial matrix by a multisubunit protein-lipid complex termed the CoQ synthome, the spatial positioning of which is coordinated by the endoplasmic reticulum-mitochondria encounter structure (ERMES). The MDM12 gene encoding...

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PMID: 39343004
DOI: 10.1016/j.jbc.2024.107820
PMCID: PMC11541779

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