Dynamic links between mechanical forces and metabolism shape the tumor milieu.

Abstract excerpt

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all physiopathological processes of tissues, mechanical forces impact the structure and function of membranes, enzymes, organelles and regulators of metabolic gene programs, thus regulating cell metabolism. In turn, metabolic pathways feedback impacts the physical properties of cell and tissues. Hence, metabolism and tissue mechanics...

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• Ecosystem
• Extracellular Matrix
• Mutation
• Neoplasms
• Tumor Microenvironment