Article

TLR4 competence and mouse models of leptospirosis

2025-02-03

Abstract excerpt

<h4> Abstract </h4> Mice are slowly being accepted as alternative models for investigation of leptospiral infection. The strain most used to analyse sublethal disease (C3H-HeJ) expresses a tlr4 gene in its immune cells that is hyporesponsive to leptospiral LPS and thus the model is deemed immunocompromised. To help resolve this valid scientific concern we did a study in which we compared infection with Leptosp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8fd79b9a-09dd-5c42-bcb4-48c7399fb63a
DOI: 10.1101/2025.02.03.636333

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TLR4 competence and mouse models of leptospirosisDOI 10.1101/2025.02.03.636333Read

Role of TLR4 in persistent <i>Leptospira interrogans</i> infection: a comparative <i>in vivo</i> study in miceSemantic proximity Read

Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes.Semantic proximity Read

TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans.Semantic proximity Read

Complement C3 Deficiency Enhances Renal Leptospiral Load and Inflammation While Impairing T Cell Differentiation During Chronic <i>Leptospira interrogans</i> InfectionSemantic proximity Read

Toll-like receptor 4-mediated respiratory syncytial virus disease and lung transcriptomics in differentially susceptible inbred mouse strains.Semantic proximity Read

The human Toll-like receptor 2 (TLR2) response during pathogenic <i>Leptospira</i> infectionSemantic proximity Read

Toll-like receptor 4-defective C3H/HeJ mice are not more susceptible than other C3H substrains to infection with Mycobacterium tuberculosis.Semantic proximity Read

Host genetics of Bordetella pertussis infection in mice: significance of Toll-like receptor 4 in genetic susceptibility and pathobiology.Semantic proximity Read

cGAS-STING dependent type I IFN protects against <i>Leptospira interrogans</i> renal colonization in miceSemantic proximity Read

CD300lf conditional knockout mouse reveals strain-specific cellular tropism for murine norovirusSemantic proximity Read

Organ-specific immune responses are strain-dependent in a mouse model of <i>Cryptococcus neoformans</i> brain infectionSemantic proximity Read

Rift Valley Fever Virus Is Lethal in Different Inbred Mouse Strains Independent of SexSemantic proximity Read