Article
TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2009
Chassin Cécilia, Picardeau Mathieu, Goujon Jean-Michel, Bourhy Pascale, Quellard Nathalie, Darche Sylvie, Badell Edgar, d'Andon Martine Fanton, Winter Nathalie, Lacroix-Lamandé Sonia, Buzoni-Gatel Dominique, Vandewalle Alain, Werts Catherine
Abstract excerpt
Leptospirosis is a widespread zoonosis caused by pathogenic Leptospira interrogans that are transmitted by asymptomatic infected rodents. Leptospiral lipoproteins and LPS have been shown to stimulate murine cells via TLRs 2 and 4. Host defense mechanisms remain obscure, although TLR4 has been shown to be involved in clearing Leptospira. In this study, we show that double (TLR2 and TLR4) knockout (DKO) mice...
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