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Article

Toll-like receptor 4-mediated respiratory syncytial virus disease and lung transcriptomics in differentially susceptible inbred mouse strains.

Physiological genomics - 1 Dec 2019

Marzec Jacqui, Cho Hye-Youn, High Monica, McCaw Zachary R, Polack Fernando, Kleeberger Steven R

Abstract excerpt

Respiratory syncytial virus (RSV) causes severe lower respiratory tract disease in infants, young children, and susceptible adults. The pathogenesis of RSV disease is not fully understood, although toll-like receptor 4 (TLR4)-related innate immune response is known to play a role. The present study was designed to determine TLR4-mediated disease phenotypes and lung transcriptomics and to elucidate transcriptional...

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Identifiers

PMID: 31736414
DOI: 10.1152/physiolgenomics.00101.2019
PMCID: PMC6962593

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