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Complement C3 Deficiency Enhances Renal Leptospiral Load and Inflammation While Impairing T Cell Differentiation During Chronic <i>Leptospira interrogans</i> Infection

2025-04-05

Abstract excerpt

Leptospirosis is a neglected zoonotic disease caused by pathogenic Leptospira spp., affecting an estimated of one million people annually and resulting in approximately 60,000 fatalities. The disease can lead to hepatic, renal, and pulmonary dysfunctions and may contribute to the development of chronic kidney disease. The Complement System plays a crucial role in eliminating bacteria by generating opsonins, anap...

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Literature Corpus work
fe3b1666-38d6-5c5a-ac04-32f455d73933
DOI
10.1101/2025.03.31.646275
Open publication

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Complement C3 Deficiency Enhances Renal Leptospiral Load and Inflammation While Impairing T Cell Differentiation During Chronic <i>Leptospira interrogans</i> InfectionDOI 10.1101/2025.03.31.646275
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