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Article

Therapy-induced transdifferentiation promotes glioma growth independent of EGFR signaling

2020-06-03

Abstract excerpt

Epidermal growth factor receptor (EGFR) is frequently amplified, mutated and overexpressed in malignant gliomas. Yet the EGFR-targeted therapies have thus far produced only marginal clinical response, and the underlying mechanism remains poorly understood. Through analyses of an inducible oncogenic EGFR-driven glioma mouse model system, our current study reveals a small population of glioma cells that can evade th...

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Identifiers and source

Literature Corpus work
8fd1337d-656b-537a-b4f7-f1a40f9b3e56
DOI
10.1101/2020.06.02.130948
Open publication

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Therapy-induced transdifferentiation promotes glioma growth independent of EGFR signalingDOI 10.1101/2020.06.02.130948
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