Article

Targeting Androgen Receptor as a Novel Radiosensitizing Therapy to Improve Long-Term Survival and Anti-tumor Immunity in Glioblastoma via TGF-β/Smad3 Axis Reprogramming

2026-02-05

Abstract excerpt

<title>Abstract</title> Glioblastoma (GBM) remains the most aggressive primary adult brain cancer with limited therapeutic options. Our prior research demonstrated that androgen receptor antagonists (ARAs) enhance survival in GBM mouse models by preferentially suppressing glioma stem cells. This study investigates the potential of ARAs as radiosensitizers in combination with radiotherapy (RT). Combined effects...

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Literature Corpus work: 95294504-7a76-55e2-ba07-88cd2ccdfe88
DOI: 10.21203/rs.3.rs-8585892/v1

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